Karyotyping from cordocentesis

Test covered by the reimbursement:
YES
Test without reimbursement:
YES
Gender:
Woman
Material:
Cultured cells
Turnover time:
2 weeks

Material:

Cultured cells | 1.5 ml of cultured cells in a microtube (Eppendorf type)
Storage after examination: 180 days 2 – 8°C

Quick test description:

Foetal karyotyping from cord blood to determine chromosomal aberrations of the foetus.

Test details:

The reason for collection is the requirement for chromosomal testing of foetal cells or testing of individual genes to exclude developmental defects in the foetus. DNA can either be directly isolated from the samples taken or used for culture under laboratory conditions. By further processing of the resulting cultures, chromosomal testing of the foetus can be performed or foetal DNA can be isolated. 

Changes in the number or structure of chromosomes are associated with serious congenital defects, which in most cases cannot be treated after childbirth. The actual culture and evaluation of the preparation usually takes between 6–14 days, so the date of collection is important. It is necessary to allow sufficient time for possible cultivation, processing and reading of the sample.

Indication

previous foetal birth with chromosomal abnormality or congenital developmental defects, stillbirth or neonatal death, carrier of chromosomal rearrangement, repeated spontaneous abortions, occurrence of sex chromosome mosaic or aneuploidy in one parent, positive screening of maternal serum, maternal age over 35 years, pathological findings on foetal ultrasound, positive screening in the first trimester, other less common indications